Analysis of Quality Influencing Factors and Coping Strategies in Site Construction Stage of Prefabricated Building

Limited to the current industry, the personnel, knowledge, and technology reserves of prefabricated buildings are not sufficient, which directly affects the engineering quality of prefabricated buildings. In particular, the quality control of the prefabricated building site construction stage is the most critical. In view of the on-site construction stage of prefabricated buildings, this paper sorts out the influencing factors of project quality from three aspects of personnel, technology and management, and from the three aspects of personnel quality, construction technology and whole process management, the coping strategies of engineering quality problems are put forward. It can effectively improve the detailed management and control of quality problems in the construction stage of the prefabricated building, and help the rapid development of the prefabricated building industry

Australobius polyspinipes sp. n., a new species of Australobius Chamberlin, 1920 (Lithobiomorpha: Lithobiidae) from China

Australobius polyspinipes sp. n. (Lithobiomorpha: Lithobiidae) was recently discovered from Tianheshan Mountain, Hebei Province, China, and it is described here. Morphologically the new species is similar to A. nodulus Ma, Song &Zhu, 2008 and A. magnus (Trozina, 1894), both recorded from China. The new species can be easily distinguished from those by having 7+7–8+8 coxosternal teeth, 10–12 ocelli on each side of the cephalic plate, 5+5 spurs on the first article of the female gonopods and differences in plectrotaxy of legs. The main morphological characters and a key to the known Chinese species of genus Australobius based on adult specimens is presented

Expression of chemokine receptor CXCR4 in nasopharyngeal carcinoma: pattern of expression and correlation with clinical outcome

Nasopharyngeal carcinoma (NPC) is a tumor derived from epithelial cells and Epstein-Barr virus infection has been reported to be a cause of this disease. Chemokine receptor CXCR4 was found to be involved in HIV infection and was highly expressed in human malignant breast tumors and the ligand for CXCR4, CXCL12 (SDF-1), exhibited high expression in organs in which breast cancer metastases are often found. The metastatic pattern of NPC is quite similar to that of malignant breast tumors. In this study, we investigated the expression of CXCR4 in nasopharyngeal carcinoma (NPC) tissues by immunohistostaining. We found different staining patterns, which included localization in the nucleus, membrane, cytoplasm or a combination of them. The staining intensity was also variable among samples. The metastatic rates in patients with high compared to low or absent expression was 38.6% versus 19.8%, respectively (P = 0.004). High expression of CXCR4 was associated with poor overall survival (OS = 67.05% versus 82.08%, P = 0.0225). These results suggest that CXCR4 may be involved in the progression of NPC and that a high level of CXCR4 expression could be used as a prognostic factor

Intrinsic Resting-State Activity in Older Adults With Video Game Experience

Playing video games is a prevalent leisure activity in current daily life, and studies have found that video game experience has positive effects in several cognitive domains. However, few studies have examined the effect of video game experience on the amplitude of low-frequency fluctuations (ALFF) among older adults. In the current study, we compared behavioral performance in the flanker task and ALFF activities of older adults, of whom 15 were video game players (VGPs) and 18 non-video game players (NVGPs). The results showed that VGPs outperformed NVGPs in the flanker task and that VGPs showed significantly increased ALFF relative to NVGPs in the left inferior occipital gyrus, left cerebellum and left lingual gyrus. Furthermore, the ALFF in the left inferior occipital gyrus and left lingual gyrus was positively correlated with cognitive performance as measured by Mini-Mental State Examination (MMSE) scores. These results revealed that playing video games might improve behavioral performance and change intrinsic brain activity in older adults. Future video game training studies in older adults are warranted to provide more evidence of the positive effects of video game experience on behavioral and brain function

Epstein-Barr virus encoded latent membrane protein 1 regulates mTOR signaling pathway genes which predict poor prognosis of nasopharyngeal carcinoma

<p>Abstract</p> <p>Background</p> <p>The oncoprotein Epstain-Barr Virus (EBV)-encoded latent membrane protein1 (LMP1) modulates the pathological effects of the NF-κB, AP-1 and JAK/STAT pathways in nasopharyngeal carcinoma (NPC).</p> <p>Methods</p> <p>Microarray analysis was performed on the NPC cell line HONE1 stably transfected with a LMP1-expression plasmid or an empty vector. Based on assigned pathways analyzed using the KEGG database, the mTOR signaling pathway was selected for verification by quantitative RT-PCR. Western blot, RNA interference and immunofluorescence were used to determine the relationship between LMP1 and mTOR signing pathway genes, and their clinical significance to NPC.</p> <p>Results</p> <p>Our studies revealed that overexpression of LMP1 upregulated the mTOR signaling pathway, possibly through phosphorylation of AKT/mTOR/P70S6K/4EBP1 in the NPC cell lines HONE1 and 6-10B. Knockdown of LMP1 reduced expression of p-mTOR and p-4EBP1 in EBV-positive NPC cell line C666-1. In addition, LMP1 expression closely correlated with expression of p-mTOR, p-P70S6K and p-4EBP1 in NPC tumors. Expression of p-P70S6K, p-4EBP1 and LMP1, but not p-mTOR, significantly correlated with overall survival of NPC patients. However, only LMP1 was an independent prognostic factor.</p> <p>Conclusions</p> <p>These results suggest that the mTOR signaling pathway is regulated by LMP1 expression in NPC. LMP1 and the genes in the mTOR pathway such as p-P70S6K and p-4EBP1 may be potential prognostic biomarkers.</p